Briefly, protein aggregates should bind to the HSP70-HSP40 complex and p97, a powerful ATPase, at the same time and then be recognized by TAX1BP1 and routed into aggrephagosomes (Krner et al., 2025)
Normal, manageable diarrhea from Ozempic typically involves 3-5 loose stools daily that can be controlled with over-the-counter treatments and dietary changes
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This gives the stool the appearance of increased mucus
This approach aims to grasp the underlying biological mechanisms in various disease states